Abstract
[Figure: see text].
Highlights
SummaryOur study found that orthostatic hypotension, even asymptomatic orthostatic hypotension, was associated with an increased risk of dementia and accelerated progression from cognitive impairment to dementia
The role of orthostatic hypotension (OH) in the continuum of cognitive aging remains to be clarified
OH can be generally divided into neurogenic OH caused by neurodegenerative disorders and nonneurogenic OH caused by other factors such as using medications that can decrease the cardiac sympathetic tone and conditions that can lead to reduced blood volume.[1]
Summary
Our study found that orthostatic hypotension, even asymptomatic orthostatic hypotension, was associated with an increased risk of dementia and accelerated progression from cognitive impairment to dementia. Further research is needed to understand the mechanisms underlying these associations This population-based cohort study of Swedish older adults aimed to increase the understanding of OH’s role in the cognitive continuum from normal cognitive function to cognitive impairment and dementia. Our study used data from 2001 to 2004 (baseline) to 2013 to 2016 and defined 3 analytical samples to address the 3 specific research objectives (Figure 1). Of the 2872 (85.4%) dementia-free people, 340 (11.8%) individuals were further excluded due to dropout, leaving 2532 persons in the dementia-free cohort (analytical sample 1). For the OH-CIND association, we used data from the baseline CIND-free cohort and further excluded 113 (6.9%) people due to lack of information to define CIND during the follow-up period, leaving 1535 participants in analytical sample 2. We used data of the CIND cohort (analytical sample 3) to analyze the association between baseline OH and the progression from CIND to dementia
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