Abstract
From nerve to blood vessel: a new role of Olfm2 in smooth muscle differentiation from human embryonic stem cell-derived mesenchymal cells.
Highlights
Vascular smooth muscle cell (SMC) differentiation is an important process in vasculogenesis and angiogenesis during embryonic development
Human embryonic stem cell can differentiate to both endothelial cell (EC) and SMC populations in the same differentiation conditions
Though the cells are excellent for in vivo neoangiogenesis and regeneration of blood vessels, they may not be ideal for precisely dissecting the molecular mechanism governing SMC differentiation because SMCs differentiated from embryonic stems cells are heterogenic and contain a mixed population
Summary
Vascular smooth muscle cell (SMC) differentiation is an important process in vasculogenesis and angiogenesis during embryonic development. SMCs originate from at least eight different progenitors during embryonic development including neural crest, proepicardium, mesothelium, splanchnic mesoderm, secondary heart field, mesoangioblasts, somites and various stem/progenitor cells[1]. Accumulating evidence has shown that a precisely coordinated molecular network orchestrates the SMC differentiation program involved in a range of signaling pathways including TGF-b, retinoid, extracellular matrix, Notch, reactive oxygen species, histone deacetylase and microRNA signaling[4].
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