Abstract
This work reviews the contributions of the corresponding author (M.M.M.P.) and her research group to Medicinal Chemistry concerning the isolation from plant and marine sources of xanthone derivatives as well as their synthesis, biological/pharmacological activities, formulation and analytical applications. Although her group activity has been spread over several chemical families with relevance in Medicinal Chemistry, the main focus of the investigation and research has been in the xanthone family. Xanthone derivatives have a variety of activities with great potential for therapeutic applications due to their versatile framework. The group has contributed with several libraries of xanthones derivatives, with a variety of activities such as antitumor, anticoagulant, antiplatelet, anti-inflammatory, antimalarial, antimicrobial, hepatoprotective, antioxidant, and multidrug resistance reversal effects. Besides therapeutic applications, our group has also developed xanthone derivatives with analytical applications as chiral selectors for liquid chromatography and for maritime application as antifouling agents for marine paints. Chemically, it has been challenging to afford green chemistry methods and achieve enantiomeric purity of chiral derivatives. In this review, the structures of the most significant compounds will be presented.
Highlights
Given the objective of this work, most of the references indicated throughout the text correspond mainly to the contribution of our group to medicinal chemistry in the chemical family of xanthones and not to shows some representative xanthones isolated by our group [35,36,37,38,39,40]
The relationship between chirality and biological activity has been of increasing importance in medicinal chemistry [121], and our group has contributed to this research field with the synthesis of a library of chiral derivatives of xanthones (CDXs)
This review aims to give a perspective of the approaches and strategies used in our group to discover bioactive xanthone derivatives, and/or pharmacological probes, from natural and synthetic sources
Summary
Xanthonesynthesis synthesisfrom from phenyl salicylate proposed by Holleman and verifed by [4,9]. AAlarge of been out, thonolignoids, bisxanthones, andhas miscellaneous xanthones terrestrial and marine sources, and concerning compounds obtained by synthesis and terrestrial andamount marine of sources, buthas alsobeen concerning by isolation synthesisfrom and Alarge research carried compounds out, not onlyobtained regarding with diversity inin medicinal, analytical and environmental chemistry. This ability of xanthones to insuch as the presence of a heteroaromatic tricyclic ring system predominantly planar and such aswith the presence a heteroaromatic system planar and terfere a variety of biological targets tricyclic is relatedring with some predominantly special molecular features rigid, a carbonyl group at the central ring able of several interactions, a biaryl ether group rigid,asa the carbonyl group the central ringtricyclic able of several interactions, a biaryl ether group such presence of aatheteroaromatic ring system predominantly planar and contributing to the electronic system, and the xanthone core that accommodates a vast rigid, a carbonyl group at the central ring able of several interactions, a biaryl ether group variety of substituents at different positions
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