From modeling, measuring, to exposomics - a Roadmap to pesticdovigilance

Abstract

BACKGROUND AND AIM: Pesticides are often linked to ill health. However, to determine the role of specific pesticides in the causation of diseases detailed high-quality exposure assessment is required. Recently, several advancements have been made in exposure assessment of pesticides varying from improved models to predict residents exposures to the use of large pesticide screens in biological fluids. METHODS: The pesticide assessment toolbox consists currently of worker, bystander and residents exposure models, a diversity of measurement techniques to quantify pesticides in different environmental domains (air, water, dust), and personal measurements through biomonitoring, omics-technologies and wearables. But which techniques can be successfully implemented in which circumstances, and what is the minimal input data needed? RESULTS:In this interactive session we will explore the roadmap towards pesticidovigilance in different populations including vulnerable populations. We will identify and discuss where the methodological and input data gaps are and how these could be overcome. CONCLUSIONS:Given the sustained public concerns around pesticide exposures it is important to facilitate better studies on pesticide and health using diverse study designs and exposure assessment methods. The outcome of this workshop should result in the formulation of the top research priorities in pesticidovigilance. KEYWORDS: Pesticides, Exposure Assessment, Wearables, OMICs, biomonitoring, Modelling