Abstract
From microdroplets to microparticles: organic particles crystallization by Spray Flash Evaporation
Highlights
Many efforts are directed to improve methods for the control the nucleation and growth of crystalline organic nanoparticles
In this work we explore the formulation of organic crystals through an easy and continuous flow processing technology that combines high rate, low energy consumption and a minimum environmental impact called spray flash evaporation (SFE)
Morphological characterizations of caffeine crystals is performed by electron microscopy, Raman spectroscopy and X-ray diffraction (XRD) which have contributed to shine light on the nucleation and growth mechanisms during the SFE process
Summary
Many efforts are directed to improve methods for the control the nucleation and growth of crystalline organic nanoparticles. Aerosol-based methods show multiple advantages such as low solvent consumption, few processing steps, easy particle collection by filtering and high production rate thanks to the possibility of operating in continuous-flow conditions.
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