Abstract
Modification of hematopoietic stem cells, in both molecular and cellular terms, has been a long-pursued goal in experimental and clinical hematology. In a recent article published in Science, Breda et al describe a novel method for the genetic modification of hematopoietic stem cells. This new experimental approach, based on the use of lipid nanoparticles, represents an important step forward in the development of genetic and cellular therapies for hematologic diseases. A general overview of the article by Breda et al and some analysis, comments, and perspectives are presented in this editorial commentary.
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