From Diagnostic Imaging to Management of Bacterial Brain Abscesses

Abstract

Advances in neuroradiological investigation have revolutionised the diagnosis and treatment of brain abscesses. CT and MR scans offer diagnostic information, disclosing the exact location, morphology and stage of infection. When these examinations fail to define the type of lesions, nuclear medicine can be called into play with scintigraphy using labelled autologous leukocytes performed with SPECT for differential diagnosis. Once the diagnosis of brain abscess is established, management is based on neuroradiological findings such as abscess stage, size, localisation and number and clinical information such as source of infection and the general clinical conditions of the patient. Conservative management is confined to small lesions at the early stage in patients whose general clinical condition is good and stable and there are no signs of intracranial hypertension. Surgery is required to treat large abscesses when the patient's general condition is poor. Different procedures are available, endoscopic evacuation aided by stereotactic systems now being the method of choice with respect to traditional excision. Neuroradiological monitoring is necessary whatever the treatment option to assess outcome and possible recurrence.