Abstract
Background Studies have shown that cAMP response element binding protein (CREB) plays an important role in learning and memorization by activating relevant gene transcription directly or indirectly.In addition,CREB which is downstream protein regulated by cyclic AMP (cAMP) involves in the learning and memory deficits caused by ketamine in minor rats.Objective To discuss the effect of ketamine,cAMP pathway and relevant regulate protein extracellular signal regulating kinase (ERK) on learning and memory. Content It has been shown that cAMP alters the phosphorylation state of protein kinase A (PKA) and activation of CREB,the latter is an important nuclear protein,its regulating promoter involves in genetic transcription of cAMP response element (CRE),which has many biological functions including regulation of learning and memory. Trend To explore a new method for treatment of learning and memory deficits induced by ketamine from cAMP and ERK signaling pathway. Key words: Ketamine; cAMP; cAMP response element binding protein; Extracellular signal regulating kinase; Phosphodiesterase 4; Learning and memory
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