FROM BENCH TO BEDSIDE: GENE EXPRESSION ANALYSIS OF THE INVASIVE FRONT IN ORAL CANCER – A SYSTEMATIC REVIEW

Abstract

This review study aims to provide an overview of the current knowledge of gene expression patterns in the invasive front of oral cancer. The invasive front is a critical region in cancer progression, where the tumor cells interact with the surrounding tissue and inuence tumor growth, invasion, and metastasis. In recent years, several studies have investigated the gene expression changes that occur in the invasive front of oral cancer, revealing the involvement of various molecular pathways and signaling networks. The review summarizes the ndings of these studies, highlighting the genes and pathways that are upregulated or downregulated in the invasive front of oral cancer. Moreover, the study discusses the potential diagnostic and therapeutic implications of these ndings, emphasizing the need for further research to improve our understanding of oral cancer pathogenesis and to develop more effective treatments. Overall, this review provides insights into the molecular mechanisms underlying the invasive behavior of oral cancer and suggests new avenues for future research in this eld.