Abstract
Reversible senescence at the cellular level emerged together with tissue specialization in Metazoans. However, this reversibility (ability to permanently rejuvenate) through recapitulation of early stages of development, was originally a part of ontogenesis, since the pressure of integrativeness was not dominant. The complication of specialization in phylogenesis narrowed this “freedom of maneuver”, gradually “truncating” remorphogenesis to local epimorphosis and further up to the complete disappearance of remorphogenesis from the ontogenesis repertoire. This evolutionary trend transformed cellular senescence into organismal aging and any recapitulation of autonomy into carcinogenesis. The crown of specialization, Homo sapiens, completed this post-unicellular stage of development, while in the genome all the potential for the next stage of development, which can be called the stage of balanced coexistence of autonomous and integrative dominants within a single whole. Here, completing the substantiation of the new section of developmental biology, we propose to call it Developmental Biogerontology.
Highlights
One of the central dogmas of unidirectional phylogenesis/ontogenesis consistently realized in evolution is a steady decrease of tissue-specific regenerative potential, implementation of which requires recapitulation of early ontogenetic stages of development and expansion of autonomous cell potential
Since the main developmental implementation mechanism is based on the predominance of integrative part (IntG), which leads to a decrease in total housekeeping genome(AHG + GHG) (THG) functionality, aging is an integral part of ontogenesis
Dedifferentiation and an increase in cell autonomy with the formation of embryonic blastema in anamniotes with poorly developed/undeveloped adaptive immune system, which are at the stage of phylogenesis, at which cell autonomy is acceptable, and a necessary component of their ontogenesis, this process leads to epimorphosis but not to carcinogenesis
Summary
One of the central dogmas of unidirectional phylogenesis/ontogenesis consistently realized in evolution is a steady decrease of tissue-specific regenerative potential (epimorphosis), implementation of which requires recapitulation of early ontogenetic (embryonic) stages of development and expansion of autonomous cell potential. Non-Aging as the Third Stage of Development new niches and improvement of all forms of life and mechanisms of adaptation, was the constant limitation of cellular autonomy in the interest of increasingly complex integrative dominants.
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