Abstract
Abstract Objectives Identify the risk profile for post-pancreatitis diabetes mellitus (PPDM) in children after a single acute pancreatitis (AP) episode, investigate episode severity's association with complications, length of stay (LOS), and intensive care unit (ICU) needs. Methods This cross-sectional study used the Pediatric Health Information System database for patients ≤19 years old with index AP admissions (2011-2020). A query (2012-2021) was performed for diabetes mellitus (DM). Patients were excluded if they had prior DM or pancreatic surgery on or before AP or DM diagnoses. Results Out of 12,822 patients with index AP admissions (median age: 13.4 years, 54% female), 686 (5.4%) developed PPDM, 320 (2.5%) during and 366 (2.9%) at a later admission. The median collective time to PPDM during and after index AP admission was 1.9 months (IQR: 0-20.8). Patients with PPDM experienced extended LOS, heightened ICU needs, and increased complications such as sepsis, pancreatic necrosis, cyst formation, along with higher rates of organ dysfunction and comorbidities. Conclusions Children face DM risks during or following AP episodes. Enhanced DM screening is crucial for patients with existing comorbidities, local or systemic complications or organ dysfunction. Close outpatient follow-up within 3-6 months of discharge from an index AP episode is recommended.
Published Version
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