Abstract
Frog Virus 3 Infection, Cultured American Bullfrogs
Highlights
American bullfrog (Rana catesbeiana) ranaculture facility suffered massive (>50%) deaths of frogs that had recently undergone metamorphosis
The family Iridoviridae is composed of Iridovirus, Chloriridovirus, Ranavirus, B
Light microscopic images of the liver (A), spleen (B), and thymus (C) showing necrosis in an American bullfrog (Rana catesbeiana) metamorph infected with frog virus 3
Summary
American bullfrog (Rana catesbeiana) ranaculture facility suffered massive (>50%) deaths of frogs that had recently undergone metamorphosis. Infection with frog virus 3 (FV3), the type species of the genus Results in edema, hemorrhage, and necrosis of lymphoid tissue, hematopoietic tissue, liver, spleen, and renal tubules [3,5]; mortality rates in free-ranging amphibians are >90% [6]. A set of fixed tissue sections from all organs was routinely processed for light microscopic examination.
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