Abstract
Diabetic kidney disease (DKD) is a chronic complication of diabetes mellitus, which is considered a worldwide epidemic. Several studies have been developed in order to elucidate possible genetic factors involved in this disease. The FRMD3 gene, a strong candidate selected from genome wide association studies (GWAS), encodes the structural protein 4.1O involved in maintaining cell shape and integrity. Some single nucleotide polymorphisms (SNPs) located in FRMD3 have been associated with DKD in different ethnicities. However, despite these findings, the matter is still controversial. The aim of this narrative review is to summarize the evidence regarding the role of FRMD3 in DKD.
Highlights
Diabetes mellitus (DM) is a complex and chronic illness involving a state of hyperglycemia [1]
In a meta-analysis, involving three studies including 1052 cases and 2057 controls, the rs10868025 single nucleotide polymorphisms (SNPs) was associated with a lower risk of diabetic kidney disease (DKD) in European type 1 diabetes mellitus (T1DM) subjects [29], whereas in a study with type 2 diabetes mellitus (T2DM) subjects [26], no significant associations between the rs10868025 SNP and DKD were detected in four independent Japanese populations
The results showed that SNPs in 4.1 protein ezrin (FRMD3) tended toward association with T2DM-end-stage renal disease (ESRD) (P < 0.05)
Summary
Diabetes mellitus (DM) is a complex and chronic illness involving a state of hyperglycemia [1]. Pezzolesi et al [25] conducted a genome wide association study (GWAS) in Caucasians with T1DM and found 13 SNPs (single nucleotide polymorphisms) associated with DKD. Maeda et al [26] analyzed polymorphic variants of this gene [25] in Japanese with type 2 diabetes mellitus (T2DM) and did not find any association with DKD.
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