Abstract
Ligands of the Wnt family activate the Frizzled-LRP5/6 receptor complex to initiate intracellular signaling. In this issue of Science Signaling, Mahoney et al. reveal a Wnt-stimulated positive feedback loop that involves local production of the lipid phosphatidylinositol(4,5)bisphosphate [PI(4,5)P2], which promotes Dishevelled recruitment and additional PI(4,5)P2 production, to facilitate LRP5/6 phosphorylation.
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