Abstract
Primary cutaneous amyloidoses (PCA) are a group of conditions characterized by deposition of amyloid in previously normal skin, without association with other skin or systemic diseases. We describe a Kazakhstani female with a 30-year history of increasingly spreading hyperpigmented macular as well papular skin lesions on her upper trunk accompanied by pruritus. Moreover, her medical history included intensely rubbing her skin with a cotton towel following bathing and showering. On the basis of the clinical and histopathological findings, the diagnosis of biphasic cutaneous amyloidosis was made. The present unusual case of biphasic cutaneous amyloidosis can be subsumed under mechanically-induced forms of cutaneous amyloidosis. In conclusion, the present case underscores the necessity to explore carefully the patient’s history in order to discover the cause of PCA.
Highlights
Primary cutaneous amyloidoses (PCA) belong to a group of conditions characterized by deposition of amyloid in previously normal skin, without association with other skin or systemic diseases [1,2,3,4]
We describe a 53-year-old Kazakhstani female with a 30-year history of increasingly spreading hyperpigmented skin lesions on her upper trunk accompanied by pruritus
Immunohistological investigations have confirmed the presence of keratin epitopes in the amyloid of biphasic amyloidosis [5,6]
Summary
Primary cutaneous amyloidoses (PCA) belong to a group of conditions characterized by deposition of amyloid in previously normal skin, without association with other skin or systemic diseases [1,2,3,4]. Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. PCA can be divided into three subtypes: (1) macular, (2) papular (lichenoid), (3) nodular. Biphasic amyloidosis is a rare entity characterized by the presence of concurrent lesions of macular and lichen amyloidosis [1,2].
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