FRI113 Increased Body Fat Is Associated With Heart Failure Of Ischemic Cause

Abstract

Abstract Disclosure: F. Bandeira: None. L.B. Oliveira: None. M.A. Siqueira: None. R.B. Gadelha: None. A.R. Correia: None. J.M. Garcia: None. F.V. Bandeira: None. M.P. Bandeira: None. Introduction: Adiposopathy is a relevant cardiovascular risk factor, being related to the onset of endothelial dysfunction and atherosclerotic disease, and has also been identified as a factor that may contribute to the onset or progression of heart failure (HF). Objective: To evaluate percent body fat (%BF) in patients hospitalized for HF and its relationship with cardiometabolic parameters and with HF etiology. Methods: Cross-sectional study was conducted in a Cardiology center, with patients aged 40 to 64 years hospitalized with HF. %BF was assessed by whole-body dual-energy x-ray absorptiometry (DXA), using the cutpoint of 25% for men or 35% for women. Coronary ischemia was confirmed by imaging tests or coronary angiograms. Results: A total of 109 patients were evaluated, of which 50.5% were female. The medians of age, length of hospital stay and left ventricular ejection fraction (LVEF) were 58 years (interquartile range [IQR] 53-61), 20 days (11-32) and 48% (34-60), respectively. 48.6% had preserved LVEF (≥50%), 11.0% mildly reduced LVEF (41-49%), and 40.4% reduced LVEF (≤40%). According to the New York Heart Association Functional Classification (NYHA-FC), 33% had NYHA-FC I-II and 67% NYHA-FC III-IV. Most patients had dysglycemia (32.1% prediabetes and 57.7% diabetes; hemoglobin A1c [HbA1c] median: 6.4% [5.8-8.4]). HF of ischemic cause was present in 57.8% of the patients. High %BF was present in 67.9%, while body mass index (BMI) in the obesity range was observed in 41.3%. High %BF was associated with ischemic HF (77.8% high %BF in ischemic HF vs. 54.3% in non-ischemic HF, p=0.010). Ischemic etiology was also associated with higher BMI (29.4 ± 5.0 vs. 26.8 ± 5.6 kg/m², p=0.012). %BF was not associated with gender (67.3% of women vs. 68.5% of men, p=0.889) or NYHA-FC (75.0% of those with NYHA-FC I-II vs. 64.4% of those with NYHA-FC III-IV, p=0.264). It was associated with higher LVEF (50.5% [36.8-62.0] vs. 37.0% [27.0-59.0], p=0.023), shorter hospital stays (18.0 [9.3-28.0] vs. 24.0 days [13.0-35.0], p=0.028), and higher serum triglycerides (139.0 [98.8-199.3] vs. 91.0 mg/dL [70.0-140.0], p=0.001). There were no associations between high %BF and HDL-cholesterol (35.0 [26.8-45.3] vs. 37.0 mg/dL [29.3-47.9], p=0.601), total cholesterol (166.0 [139.0-189.3] vs. 164.0 mg/dL [129.0-193.5], p=0.594) or HbA1c levels (6.25% [5.8-8.4] vs. 6.5% [5.6-8.7], p=0.990). Conclusion: Our data demonstrated larger increases in body fat from patients admitted with HF of ischemic cause, which was associated with shorter hospital stay and higher serum triglycerides concentrations. Presentation: Friday, June 16, 2023