FRI0676 PREVALENCE AND UVEITIS CHARACTERISTICS OF A COHORT OF PATIENTS WITH SPONDILOARTROPATHY

Abstract

Background Uveitis can be a clinical manifestation of different systemic processes, known is the association of anterior uveitis in patients with spondyloarthritis (SpA) Objectives To describe the prevalence, characteristics and course of ocular inflammatory pathology from a cohort of patients with SpA Methods Retrospective descriptive study made in a cohort of 451 SpA patients according to the ASAS classification criteria in a a tertiary university hospital from Barcelona. Were selected patients who presented or had presented uveitis (defined according to the SUN1 classification criteria) Demographic, clinical, radiological and serological data of the joint disease and characteristics of the ocular affectation were collected, as well as the treatment of both Results Of the 451 patients reviewed, 43 (9.53%) patients with a history of uveitis were included in the study. From the cohort, the average age at diagnosis of SPA was 37 (± 27) years and 38 (88.4%) had positive HLAB27. The most prevalent subtypes of SPA were Ankylosing Spondylitis (AS): 27 (62.8%) and Psoriatic Arthritis (APSo): 8 (18.6%). The characteristics of the sample are summarized in Table 1 The average age at the first uveitis outbreak was 45 ± 23 years. The anterior location was more prevalent (n: 39, 90.7%), unilateral (n: 35, 81.4%) and acute onset (n: 42, 97.6%) Two of patients with anterior uveitis had other associated complications, one had macular edema and other retinal vasculitis. The treatment of uveitis was topical corticosteroids in 39 (90.6%) patients, 2 (4.6%) treatment with oral sulfasalazine. Despite the treatment, 22 (51.2%) patients presented a recurrent course. Table 2 shows the ocular clinical features Conclusion In our cohort of SPA, prevalence of uveitis was 10%, predominantly in HLA B27 patients and axial involvement, of which 62.8% met criteria for AD and 18.6% APSO with different degrees of axial involvement, including under systemic treatment (FAMEs/Biological). The most frequently presentation was anterior, unilateral, acute and recurrent uveitis. Being the most used treatment topical corticosteroids.