Abstract
Background Type 2 diabetes mellitus (T2DM) is a risk factor for osteoporotic fractures although bone mineral density is normal or even increased, Thus, diabetes may be associated with a reduction of bone strength that is not reflected in the measurement of bone mineral density (BMD) Objectives The aim of this study was to compare BMD with a non invasive assessment of trabecular microarchitecture, (Trabecular bone score) TBS, in patients with T2DM Methods In a prospective cross-sectional study, trabecular microarchitecture was examined in patients with T2DM and non diabetic control subjects. The exclusion criteria were diseases (hyperthyroidism, Cushing’s syndrome, primary hyperparathyroidism, renal failure, malabsorption), rheumatic diseases and/or medications that might affect bone and mineral metabolism,post menopausal women. Lumbar spine BMD was measured by dual-emission x-ray absorptiometry (DXA), and TBS was calculated by examining pixel variations within the DXA images using TBS iNsight Results 205 patients (108 male, 97 female), aged 25 to 60 years with T2DM and 205 non diabetic control subjects ((105 male, 100 female) Mean TBS was lower in T2DM (1.256±0.103 vs. 1.291±0.101, p=0.001). Mean BMD was higher in T2DM Z score (0.516±1.346 vs. -0.8151±1.153, p= 0.016). Conclusion In T2DM,TBS is lower than control subjects. Abnormal trabecular microarchitecture may help explain the paradox of increased fractures at a higher BMD in T2DM References [1] Dhaliwal R, Cibula D, Ghosh C, Weinstock RS, Moses AM. Bone qualityassessment in type 2 diabetesmellitus. OsteoporosInt.2014;25:1969-73. -Leslie WD, Aubry-Rozier B, Lamy O, Hans D. TBS (Trabecular Bone Score) and Diabetes-Related Fracture Risk. J Clin EndocrinolMetab.2013;98:6029. -Kim JH, Choi HJ, Ku EJ, Kim KM, Kim SW, Cho NH, et al. Trabecular Bone Score as an Indicator for Skeletal Deterioration in Diabetes. J Clin EndocrinolMetab.2015;100:475-82. Disclosure of Interests None declared
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