FRI0461 GENETIC ANALYSIS OF THE NF-KB PATHWAY CAN BE USEFUL TO DISTINGUISH PATIENTS AT RISK OF PSORIATIC ARTHRITIS WITHIN THE SPECTRUM OF PSORIATIC DISEASE

Abstract

Background Psoriasis and psoriatic arthritis (PsA) are the main manifestations of what is now known as psoriatic disease. Both entities share common genetic pathways, but they also differ. The NF-κb pathway has been implicated in the genesis of psoriatic disease, but the differential contribution of this genetic pathway to the risk of psoriasis and PsA is not fully understood1. Objectives Our aim was to study the association of common polymorphisms at genes of the NF-κb pathway in patients with psoriatic disease. Methods The study involved a total of 690 psoriatic disease patients (187 of them with PsA) and 550 controls. We genotyped three common polymorphisms in NFKB1 (rs230526), NFKBIA (rs7152376) and NFKBIZ (rs3217713 indel) and compared allele and genotype frequencies between cases and controls. Results The rare NFKBIA rs7152376 C was significantly more frequent in the PsA group vs. controls (0.42 vs. 0.36; p=0.04, OR=1.29, 95%CI=1.02-1.63). Compared to skin psoriasis, PsA patients showed a significantly higher frequency of the rs7152376 C (0.42 vs. 0.31; p Conclusion We found a significant association between NFKBIA variants and PsA. Our study shows that alterations in the same genetic pathway may have differential effects on different manifestations of psoriatic disease. Additional studies from larger cohorts and different populations are necessary to validate these results.