FRI0295 EVALUATION OF CLINICAL CHARACTERISTICS IN BEHCET SYNDROME BY GENDER AND AGE; A SINGLE CENTER EXPERIENCE WITH 665 PATIENTS

Abstract

Background To evaluate clinical characteristics according to age and gender in patients with Behcet’s Syndrome (BS). Objectives BS is a systemic vasculitis that affects mucosa, skin, joint, eye, vessels, gastrointestinal system, and central nervous system. The disease characterizes by relapses and remissions, and it is known that prognosis is worse in young males. The aim of this study was to reinvestigate the relationship between the clinical features of BS according to gender and age. Methods The data of 665 patients (282 male, 383 female), diagnosed as BS according to the ISG-1990 Behcet’s Disease classification criteria, were retrospectively evaluated. Results All patients had oral aphthous (OA) ulcers (100%). Eighty-five percent of patients had a genital ulcer (GU), 56.5% had erythema nodosum (EN), 65.9% had papulopustular lesions (PPL), 32.6% had ocular involvement, 49.3% had joint involvement, and 21.7% vascular involvement, and 4.8% had neurobehcet. The incidence rates of PPL, ocular involvement, and vascular involvement were significantly higher in males (p Conclusion Clinical features of BS may vary according to age and gender. Variations can be observed depending on the size of the population, the center where the study is conducted, and the selected-criteria for inclusion. In our study, PPL, ocular involvement and vascular involvement were more frequent in men, whereas GU, joint involvement, headache, and pathergy positivity were more common in women. In addition, GU, EN, and vascular involvement were related to younger ages. Our results were compatible with the BS literature. References None Disclosure of Interests None declared