FRI0241 PREGNANCY RATES AND PERINATAL OUTCOMES AMONG WOMEN WITH SYSTEMIC LUPUS ERYTHEMATOSUS IN COMPARISON TO GENERAL POPULATION

Abstract

Background: Systemic lupus erythematosus (SLE) can affect people of all ages, but it occurs most often during childbearing ages. It has been documented that the fertility rates in women with SLE is similar to those without SLE. On the other hand, the pregnancy adverse outcomes are common in pregnant women with SLE. However, the pregnancy rates in women with SLE was not fully understood. In addition, comparison of the pregnancy adverse outcomes with general population is limited. Objectives: We estimated the pregnancy rates and adverse pregnancy outcomes in Korean women with SLE and compared them with women without SLE. Methods: Among all women aged 15-49 years in the Korean National Health Insurance claim database from January 2013 to December 2015, pregnant women were identified by using ICD-10 code for delivery and abortion. Pregnant women were categorized into women with SLE and control group. Adverse pregnancy outcomes classified into five categories as follows: fetal loss, intrauterine growth retardation (IUGR), preterm delivery, pre-eclampsia or eclampsia, and gestational diabetes mellitus. Crude incidence rates (IRs) of pregnancy and adverse pregnancy outcomes were calculated. Incidence rate ratios (IRRs) of those were estimated and adjusted for age. Results: In SLE, 994 pregnancy cases were observed during the study period. The crude estimated IRs of pregnancy were lower in SLE patients than general population (Table 1). Age-adjusted IRR was also lower in SLE patients (Table1). The adjusted-IRR of live birth in SLE pregnant women was 0.92 (95% CI 0.85 - 0.99) compared with control group. The adjusted-IRR of fatal loss, IUGR, and preterm delivery was 1.27 (95% CI 1.11 - 1.45), 4.52 (95% CI 3.45 - 5.91), and 3.25 (95% CI 1.62 - 6.52), respectively. The IRR of pre-eclampsia or eclampsia was 3.21 (95% CI 2.52 - 4.08), but those of gestational diabetes mellitus was not significant (IRR 0.89, 95% CI 0.80 - 1.00). Conclusion: Pregnancy rates in SLE women were lower about 30% compared with general population. Pregnancy adverse outcomes were higher in SLE pregnant women with more than 4-fold IUGR and pre-eclampsia/eclampsia, 3.2-fold preterm delivery.