FRI0082 Ras signaling inhibitors attenuate arthritis in animal models of rheumatoid arthritis by down modulating the pathogenic th17 cell response

Abstract

BackgroundRas-GTPases are vital for normal T cell activation, and downstream effectors of Ras include the MEK/ERK, PI3-kinase/AKT, mTOR/p70S6-kinase, and NF-kB pathways. Somatic mutations in NRAS cause an autoimmune lymphoproliferative disorder...