FRI-206 - High Levels of Immunoglobulin a Anti-Tissue Transglutaminase Antibodies at Diagnosis are a Predictive Factor for Celiac Hepatitis

Abstract

AbstractIntroduction: Celiac hepatitis is characterized by the presence of liver injury in patients with celiac disease that resolves after gluten-free diet.Aim: To evaluate predictive factors of celiac hepatitis at celiac disease diagnosis.Methods: Retrospective study including 46 adult patients with the diagnosis of celiac disease.Results: Eighty-seven percent were women, with a mean age of 33 ± 11 years, 87% had a Marsh 3 and 46% (n = 21) had celiac hepatitis. These patients had a median Immunoglobulin A anti-tissue transglutaminase antibody (TTG-IgA) level of 208.0 U/ml (p25–p75: 89–1316 U/ml), a mean aspartate aminotransferase of 42 ± 24 U/L, alanine aminotransferase 50 ± 28 U/L, alkaline phosphatase 111 ± 64 U/L, at the time of diagnosis. Median TTG-IgA one year after diagnosis was 9U/ml (p25–p75: 4.5–30.5 U/ml) and 33% of the patients had normal values. At diagnosis, patients without celiac hepatitis had a median TTG-IgA of 77U/ml (p25–p75: 24–288 U/ml), mean aspartate aminotransferase of 23 ± 4 U/...