Abstract
Bacterial regulatory RNAs have been defined as diverse classes of cis and trans elements that may intervene at each step of gene expression, from RNA and protein synthesis to degradation. Here, we report on a few examples from Gram-positive bacteria that extend the definition of regulatory RNAs to include 5' and 3' UTRs that also act as cis and trans regulators. New examples unveil the existence of cis and trans acting regulatory RNAs on a single molecule. Also, we highlight data showing that a key RNA chaperone in Enterobacteriaceae, Hfq, does not fulfill the same role in Gram-positive Firmicutes.
Highlights
Bacterial survival results from the capacity of the cell to coordinate the expression of genes in response to changing environmental conditions, allowing it to adapt and gain novel niches
We report on a few examples from Grampositive bacteria that extend the definition of regulatory RNAs to include 50 and 30 untranslated regions (UTRs) that act as cis and trans regulators
The Hfq protein is a key RNA chaperone in Enterobacteriaceae involved in the vast majority of RNA duplexes formed between a trans-regulatory RNA and its messenger RNAs (mRNA) target
Summary
Bacterial survival results from the capacity of the cell to coordinate the expression of genes in response to changing environmental conditions, allowing it to adapt and gain novel niches. We report on a few examples from Grampositive bacteria that extend the definition of regulatory RNAs to include 50 and 30 UTRs that act as cis and trans regulators. This review highlights recent discoveries of diverse mechanisms whereby RNA mediates gene regulation in Gram positive bacteria.
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