Abstract
All LTNPs revealed at least one genetic defect in 4 genes, whereas controls revealed it in both 5’ LTR/gag and nef genes. Overall genetic defects were significantly higher in LTNPs (11.4%) than 4.9% in controls (P < 0.001). Among the 4 LTNPs, one patient who had taken the least amount of KRG revealed significantly higher proportion of premature stop codons (5.6%) than 1.6% in 3 LTNPs (P < 0.01). There was a significant difference in the frequency of genetic defects between on KRG (10.9%) and baseline prior to KRG intake (4.3%) (P < 0.01). There was a significant correlation between amount of KRG supplied and proportion of genetic defects (r=0.80, P < 0.05). At single gene level, only the nef gene showed a significantly higher frequency of genetic defects in LTNPs (11.5%) than 3.6% in controls (P < 0.01). Conclusion
Highlights
The association between long-term nonprogressors (LTNPs) and genetic defects in HIV-1 is not clear because of paucity of genetic defects in LTNPs
To investigate whether LTNPs are associated with genetic defects, we amplified near fulllength HIV-1 sequences in 10 overlapping fragments (0.8 to 1.4 kb) using nested PCR with peripheral blood mononuclear cells
Overall genetic defects were significantly higher in LTNPs (11.4%) than 4.9% in controls (P < 0.001)
Summary
The association between long-term nonprogressors (LTNPs) and genetic defects in HIV-1 is not clear because of paucity of genetic defects in LTNPs. Materials and methods A total of 250 individuals were diagnosed with HIV-1 infection in Korea before 1993. Among the 250 individuals, we selected all who remain healthy for >18 years in the absence of antiretroviral therapy.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
