Abstract
Germline genetic testing guides gastroenterologists’ recommendations for prevention of gastrointestinal malignancies. This is well-appreciated for individuals at highest risk for colorectal cancer, including Lynch syndrome or polyposis syndromes.1 In the case of pancreatic cancer (PC), several inherited cancer susceptibility genes are associated with increased PC and breast cancer risk, including BRCA1 and BRCA2, ATM, and PALB2.1-3 With increased multigene panel testing performed for personal and family history (FH) of cancer, and recent National Comprehensive Cancer Network guidelines that recommend genetic testing for those with first-degree relatives diagnosed with PC, newly identified carriers of pathogenic variants will seek recommendations from gastroenterologists on PC screening and outcomes.
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