Frequency, times, and type of metastasization of transplantable tumors in mice

Abstract

The character of metastasization of nine strains of transplantable mouse tumors injected by the usual subcutaneous method was studied. Differences were observed in the frequency, intensity, and types of metastasization of different tumors. Latent periods of onset of metastases of Lewis and RL-67 lung carcinomas and of sarcoma-37 were determined. Sarcoma-37, Lewis and RL-67 carcinomas of the lung, AKATOL adenocarcinoma of the large intestine, and Cloudman's and B-16 melanomas metastasized most intensively. Sarcoma-37, metastasizing into the lungs, RL-67 lung carcinoma metastasizing into the lungs, kidneys, adrenals, ovaries, and heart, and adenocarcinoma of the large intestine AKATOL, forming metastases in the lymph nodes and liver, can be used as models for seeking methods of chemotherapeutic action on metastases and metastasization.