Abstract
Introduction: The failure of DNA repair genes is the main reason for cancer development in human beings. The normal X-ray repair cross-complementing Group1 (XRCC1) gene play a key role in base excision repair (BER) pathway. The occurrence of XRCC1 exon 10 G>A polymorphism varies in different ethnic groups and the data on the allelic distribution of the same is lacking in Saudi Arabian population. The objective of the current study was to delve deep into the documented studies and analyze the frequency of genetic polymorphism XRCC1 exon 10 G>A in Saudi Arabian population and further do the comparison with other ethnic groups of the world. Methods: PUBMED (Medline), web-databases was searched for the required epidemiological studies of different ethnic group. Results: The frequency of XRCC1 exon 10 variant allele (A) was found to be 22.3%. Further this frequency was compared with various others ethnic groups and a significant difference was found for Thailand (p=0.001), Iran (p=0.025), Japan (p=<0.001), North India (p=<0.001), Poland (p=0.010), France (p=0.001), Norway (p=<0.001), USA (p=<0.001), Pakistan (p=<0.001), Spain (p=<0.001), Belgium (p=<0.018), Australia (p=<0.001), and Portuguese (p=<0.045) population. Conclusions: The overall results of this study suggest that frequency of this DNA repair genes demonstrates distinctive pattern in Saudi Arabia population, which might be possible because of ethnicity variation. This could assist in high-risk screening of humans exposed to environmental carcinogens and cancer predisposition in different ethnic groups.
Highlights
The failure of DNA repair genes is the main reason for cancer development in human beings
The number of publications identified and considered for the current study were 22 which were based on the prevalence of X-ray repair cross-complementing Group1 (XRCC1) exon 10 (G>A)
(p=
Summary
The failure of DNA repair genes is the main reason for cancer development in human beings. Conclusions: The overall results of this study suggest that frequency of this DNA repair genes demonstrates distinctive pattern in Saudi Arabia population, which might be possible because of ethnicity variation. This could assist in high-risk screening of humans exposed to environmental carcinogens and cancer predisposition in different ethnic groups. The different environmental agents like ionizing radiations result in damage to DNA of the exposed cells This causes the loss of integrity of the genetic information, which further leads to manifold increase in cancer risk. They are present in at least 1% population (Collins et al 1997) and are usually less penetrant, but their study in cancer is very important (Perera et al 2000)
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