Frequency of varicella zoster virus DNA in human adrenal glands.

Abstract

Varicella zoster virus (VZV) becomes latent in ganglionic neurons derived from neural crest cells. Because the adrenal gland also contains medullary chromaffin cells of neural crest origin, we examined human adrenal glands and medullary chromaffin cell tumors (pheochromocytomas) for VZV and herpes simplex virustype 1 (HSV-1). We found VZV, but not HSV-1, DNA in 4/63 (6%) normal adrenal glands. No VZV transcripts or antigens were detected in the 4 VZVDNA-positive samples. No VZV or HSV-1 DNA was found in 21 pheochromocytomas.