Abstract
Objective:To determine the frequency of urinary tract infections and antibiotic sensitivity among patients with diabetes.Methods:This observational study was carried out in Microbiology Department of Baqai Institute of Diabetology and Endocrinology (BIDE), Baqai Medical University from April 2015 to June 2016. All patients with diabetes having symptoms of UTI attending out patients department of BIDE were analyzed. All samples received in the laboratory were processed according to Clinical and Laboratory Standards Institute (CLSI) guidelines. Antimicrobial susceptibility pattern was determined by disc diffusion method.Results:A total number of 199 urine specimens, frequency of UTI were 24 (12.06%) in male and 175 (87.94%) in female. UTIs were highly found in (age group 51-60) 70 (35.18%). Escherichia coli was the most frequent pathogen (71%), followed by Klebsiellapneumoniae (7.48%), Proteus mirabilis (1.87%), Staphylococcus aureus (9.35%), Candida (5.61%) and Candidaalbicans were (2.80%). Majority of gram negative uropathogens were shown high sensitivity towards Imipenem and Piperacillin / Tazobactam followed by Nitrofurantion, Ceftriaxone, Levofloxacin, Ofloxacine, Ciprofloxacin, Norfloxacin, Cefixime, Nalidixic acid and Cephradine. Gram positive was most sensitive to Nitrofurantionand Vancomycin followed by Piperacillin / Tazobactam, Imipenem, Cephradine, Ceftriaxone, Norfloxacin and Cefixime.Conclusion:We observed the higher frequency of UTIs in female as compared to male participants due to poor hygiene. E.coli was the most frequent pathogen responsible for UTI in patients with diabetes, followed by Staphylococcus aureus.
Highlights
Diabetes mellitus (DM) is becomes a global health issue to health care professionals.1 According to International Diabetes FederationCorrespondence: December 1, 2018 June 26, 2019 July 10, 2019 August 6, 2019(IDF) 451 million people was reported with diabetes worldwide 415 million people in 2017, which expected to increase to 693 million) in 2045.2 Approximately 7.5 million Pakistani people suffer from DM.3 Patients with diabetes are at high risk of urinary tract infections (UTI) and its complications especially in patients with Type-2 diabetes
August 6, 2019 (IDF) 451 million people was reported with diabetes worldwide 415 million people in 2017, which expected to increase to 693 million) in 2045.2 Approximately 7.5 million Pakistani people suffer from DM.3
Escherichia coli (E.coli) was the most common among Gram negative isolate 77 (71.96%) of total isolates followed by K.pn 8 (7.48%) and Proteus mirabilis (P.mir) 2 (1.87%)
Summary
Diabetes mellitus (DM) is becomes a global health issue to health care professionals. According to International Diabetes FederationCorrespondence: December 1, 2018 June 26, 2019 July 10, 2019 August 6, 2019(IDF) 451 million (age 18-99 years) people was reported with diabetes worldwide 415 million people in 2017, which expected to increase to 693 million) in 2045.2 Approximately 7.5 million Pakistani people suffer from DM. Patients with diabetes are at high risk of urinary tract infections (UTI) and its complications especially in patients with Type-2 diabetes. (IDF) 451 million (age 18-99 years) people was reported with diabetes worldwide 415 million people in 2017, which expected to increase to 693 million) in 2045.2 Approximately 7.5 million Pakistani people suffer from DM.. Patients with diabetes are at high risk of urinary tract infections (UTI) and its complications especially in patients with Type-2 diabetes. A survey reported UTI to be the most common microbial infection worldwide.. A survey reported UTI to be the most common microbial infection worldwide.4 It was estimated about 150 million people each year affected from this infection. It is most common in women than in men and about 50-60% of women suffering from it at least one time during their lifetime.. It is most common in women than in men and about 50-60% of women suffering from it at least one time during their lifetime. UTI pose a clinical problem elevates the risk of pyelonephritis, premature delivery, and fetal mortality among
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