Frequency of the minor BCR-ABL (e1;a2) transcript oncogene in a Mexican population with adult acute lymphoblastic leukaemia

I Olarte-Carrillo,C.O Ramos-Peñafiel,E Miranda-Peralta,I Mendoza-Salas,K.A Nacho-Vargas,J.A Zamora-Domínguez,E Mendoza-García,E Rozen-Fuller,J.J Kassack-Ipiña,J Collazo-Jaloma,A Martínez-Tovar

doi:10.1016/j.hgmx.2015.08.001

I Olarte-Carrillo, C.O Ramos-Peñafiel + Show 9 more

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https://doi.org/10.1016/j.hgmx.2015.08.001

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Abstract

BackgroundThe minor BCR-ABL (e1;a2) transcript oncogene is the most common genetic alteration in adults with acute lymphoblastic leukaemia (ALL). It is associated with a poor prognosis. AimTo determine the frequency of minor BCR-ABL (e1;a2) transcript oncogene expression in ALL patients in Mexico. Material and methodsA cohort of 411 patients with de novo ALL were tested for the oncogene using reverse transcription polymerase chain reaction (RT-PCR). ResultsThe oncogene was found in 14% (n=57) of the study population. Mean age was 29 years, and 53% were male. Median leucocyte count was 53×103μl. ConclusionPrevalence of BCR-ABL expression by RT-PCR has not previously been reported in Mexico. Our laboratory found a higher prevalence than that reported in Latin-American series, but lower than that reported for the European population.

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