Abstract
Frequency of overexpression of Her2/neu in colorectal adenocarcinomas– A hospital based cross-sectional study - IJPO- Print ISSN No: - 2394-6784 Online ISSN No:- 2394-6792 Article DOI No:- 10.18231/j.ijpo.2020.006, Indian Journal of Pathology and Oncology-Indian J Pathol Oncol
Highlights
Colorectal malignancies stand out to be one of the chief causes of morbidity and mortality in the world
In the present study we aim to determine the frequency of overexpression of HER2/neu in colorectal adenocarcinomas, to study the association between HER2/neu overexpression with age and gender of the patient and grade, type and stage of the tumour and to study the various histomorphological changes in colorectal adenocarcinomas
A total of 52 cases were assessed for HER2/neu status .24(46.1%) cases were negative(score 0 and score 1), 16(30.8%) cases were equivocal(score 2) and12(23.1%) cases were positive(score 3)
Summary
Colorectal malignancies stand out to be one of the chief causes of morbidity and mortality in the world. The total incidence of colorectal malignancy in India n population has marginally increased, it is a common cause of cancer mortality among Indians. The scores were correlated with histological grade, type and clinicopathological parameters. Conclusion: Histological grade and histological type of CRC showed a significant correlation with HER2/neu overexpression, can be used as a predictive tool for determining the prognosis of the patients. Patients who overexpress HER2/neu could become potential candidates for this monoclonal antibody based targeted immunotherapy reduce overall mortality and morbidity of CRC worldwide. Similar to other epidermal growth factor receptors HER1, HER3, and HER4, The human epidermal growth factor receptor (HER 2/neu) is located on chromosome 17q21 Chemotherapy with Herceptin is found to improve the prognosis of the patients. 2
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