Abstract
Background: Non-motor symptoms (NMS), including neuropsychiatric, sleep, autonomic, and sensory domains, are an integral aspect of the clinical presentation of Parkinson disease (PD) and affect neurocognitive functioning as well as patients' and caregivers' well-being.Objective: To describe the occurrence of NMS in PD patients with motor fluctuations in real-life condition.Methods: The present study is a secondary analysis of a previous multinational, multicenter, retrospective-prospective cohort observational study (SYNAPSES). Patients with PD diagnosis and motor fluctuations aged ≥18 years were included. Data collected at the baseline visit were used for this study, and descriptive analyzes were conducted to describe the distribution of NMS in motor-fluctuating PD patients distributed according to different clinical characteristics.Results: Of the 1,610 patients enrolled, 1,589 were included for the analysis (978 males and 611 females), with a mean age of 68.4 (SD = 9.6). Most patients had at least one NMS (88.5%). Sleep problems and psychiatric symptoms were the most prevalent NMS in motor fluctuating PD patients in all H and Y stages. Psychiatric disorders were more frequent in older patients and in patients with a larger number of years of PD diagnosis, while sleep problems were more preeminent in younger patients and with inferior disease duration.Conclusions: The present findings further support the high prevalence of NMS in PD patients with motor fluctuations, thus reinforcing the need for assessing them for diagnostic accuracy and for delivering holistic care.
Highlights
The occurrence of dyskinesias and motor fluctuations, such as wearing off and on-off effects, is a crucial problem in the longterm management of patients with Parkinson’s disease (PD) [1, 2]
It has been documented that advanced PD patients with motor fluctuations tend to report non-motor symptoms (NMS) more frequently than mild-moderate patients, and the NMS themselves tend to be more severe and sometimes fluctuating [9]
From the first description of NMS, it has been documented that a large proportion of PD patients may show neuropsychiatric disturbances, sleep disorders, fatigue, gastrointestinal symptoms, autonomic dysfunction, and sensory complaints [10,11,12,13]
Summary
The occurrence of dyskinesias and motor fluctuations, such as wearing off and on-off effects, is a crucial problem in the longterm management of patients with Parkinson’s disease (PD) [1, 2]. Motor fluctuations are related to a variety of factors, including the age of disease onset, disease duration, duration of treatment, disease severity, and dose of levodopa [3,4,5,6,7,8]. From the first description of NMS, it has been documented that a large proportion of PD patients may show neuropsychiatric disturbances, sleep disorders, fatigue, gastrointestinal symptoms, autonomic dysfunction, and sensory complaints [10,11,12,13]. Non-motor symptoms (NMS), including neuropsychiatric, sleep, autonomic, and sensory domains, are an integral aspect of the clinical presentation of Parkinson disease (PD) and affect neurocognitive functioning as well as patients’ and caregivers’ well-being
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
