Abstract
Objective:To determine frequency of Minimal Hepatic Encephalopathy in illiterate patients with compensated cirrhosis.Methods:Illiterate patients with compensated cirrhosis with F4 Score on Shear-wave Elastography were selected for study after informed consent. Sample size was estimated at 106. Selected patients were subjected to two tests for detection of MHE, Number Connection Test A and Block Design Test. Patients taking ≥ 30 seconds were labelled as Positive for MHE.Result:Out of 110 selected patients 10.9% were alcoholics and in 8.2% of patients no hepatic virus infection was detected. HCV was positive in 48.2% patients while HBV was positive in 13.6% of patients. MHE was detected in 72 (65.5%) of patients. Major differences were found in MHE Stage II & III by two tests. Over all BDT detected more cases and gave higher Staging in Stage II & III as compared to NCT-A test.Conclusion:Minimal Hepatic Encephalopathy (MHE) could be detected in illiterate patients using NCT-A and BDT Tests.
Highlights
Hepatic Encephalopathy (HE) is a common and frequent complication of cirrhosis.[1]
Minimal Hepatic Encephalopathy (MHE) is a complication occurring in cirrhosis due to neuro-cognitive dysfunction
Illiterate patients with compensated cirrhosis with F4 Score on Shear-wave Elastography were selected for study after informed consent
Summary
Hepatic Encephalopathy (HE) is a common and frequent complication of cirrhosis.[1]. It continues to remain as a major complication in patients with chronic liver disease despite advances in. About 30-45% of patients with cirrhosis develop HE which ranges from mild symptoms like easy fatigue and sleep inversion to full blown coma.[2] HE is associated with reduced survival even after its single episode.[3] Minimal Hepatic Encephalopathy (MHE) is a complication occurring in cirrhosis due to neuro-cognitive dysfunction It is characterized by specific complex cognitive dysfunction which is independent of sleep dysfunction or problems with overall intelligence. These cognitive shifts are missed during routine clinical examination and identified uniquely through psychometric or neurological tests.[4,5] named “minimal”, it has far reaching impact on quality of life, ability to function in daily life and can progress to overt hepatic encephalopathy.[4] The prevalence of MHE in HE is reported as 30-84%.5. Objective of this study was to determine frequency of Minimal Hepatic Encephalopathy in illiterate patients with compensated cirrhosis
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