Frequency of individual nosological units, metabolic syndrome and obesity in patients with adrenal hormonally inactive adenomas and their relationship with anthropometric indicators

Abstract

Introduction: The diagnosis of adrenal hormonally inactive adenoma is made when a precise endocrine examination rules out the presence of hormonal oversecretion. More and more data indicate an association between hormonally inactive adrenal adenomas and some components of cardiometabolic risk—insulin resistance, obesity, hypertension, hyperglycemia and dyslipidemia. Aim: The main goal of the present study is to determine the frequency of individual nosological units, metabolic syndrome and obesity in patients with adrenal hormonally inactive adenomas and their relationship to anthropometric indicators. Material s and Methods: The subject of the study were 105 patients with hormonally inactive adrenal adenomas, passed through the Clinic of Endocrinology and Metabolic Diseases at St. Marina University Hospital. The results are processed with SPSS v. 20.0, using variance, variation, correlation and comparative analyses, and risk assessment analysis. We take p < 0.05 as the significance level. Results: A proportionally weak relationship between gender and waist circumference has been established. There is a significant difference in the relative share of men and women with HDL level above the norm (p < 0.001). In addition, BMI, arterial hypertension, cholesterol, HDL and fasting blood glucose does not correlate with gender. Triglycerides are found to have a weak correlation with gender. A significant difference was found in the relative proportion of men with serum HDL levels < 1.03 mmol/L with a waist circumference below and above 94 cm (p = 0.001), and there is an inversely proportional moderate dependence between waist circumference in men with inactive adrenal glands adenomas and serum HDL levels (r = -0.369; p < 0.001). It is found that men with hormonal inactive adrenal adenomas, having waist circumference > 94 cm have an 8 times higher risk of decreased serum HDL levels (OR = 8.0) (2.43-26.33); p < 0.001). A positive moderate dependence was found between uric acid serum levels with GGT and FLI. Conclusion: Additional research is needed to conclude whether these patients have an altered metabolic profile and have a statistically increased risk of cardiovascular disease and mortality.