Frequency of Hyperuricemia in Type-2 Diabetes Mellites and its Relation with Diabetic Nephropathy

Abstract

Objectives: To determine the frequency of Hyperuricemia in patients with type-2 Diabetes Mellitus and to compare frequency of Diabetic Nephropathy in Hypouricemic vs Normouricemic patients with type-2 Diabetes.
 Study Design: Cross-sectional analytical study.
 Duration and Place of Study: Medicine Department Combined Military Hospital Peshawar, from Dec 2018 to May 2019.
 Methodology: Patients from both genders with type 2 Diabetes having glycosylated hemoglobin (HbA1c) ≥6.5%, Fasting Blood glucose ≥ to 7.0 mmol/L or random blood glucose ≥11.1 mmol/L were recruited from out Patient department.Participants were tested for serum uric acid, fasting blood glucose, Glycosylated hemoglobin (HbA1c) and Spot Urine Albumin Creatinine Ratio after 8 hours fasting.
 Results: Out of 111 patients enrolled Hyperuricemia was present in 40 (36.04%) patients of which 21 (52.50%) were male and 19 (47.50%) were female. Diabetic Nephropathy was present in 43(38.74%). Out of 43 patients having diabetic nephropathy, 25 (58.14%) were having hyperuricemia. The study observed a linear relationship between serum uric acid and type-2 diabetes duration, fasting blood glucose levels, glycosylated hemoglobin (HbA1c) and urinary Albumin creatinine ratio.
 Conclusion: Hyperuricemia is positively linked with diabetic complications in majority of patients with type-2 diabetes. Serum uric acid levels can be used as an early diagnostic parameter and can prognosticate diabetic nephropathy.Keywords: Diabetes mellitus, Diabetic nephropathy, Hyperuricemia, Microalbuminuria