Abstract
BackgroundIdentification of different HPV subtypes in unidentified communities provides sufficient information for screening and monitoring potential impact of a vaccination program. Therefore, the aim of this study was to screen for the presence of HPVs subtypes 31,33,35,39 and 45 among Yemeni women with Cervical Cancer.MethodologyA total of 200 (150 malignant and 50 benign) tissue samples were obtained from Yemeni women with cervical cancer, were investigated for the presence of HPV subtypes 31,33,35,39 and 45 by Polymerase Chain Reaction (PCR).ResultsOf the 150 cervical cancer tissue specimens, HPV 31, HPV 33, HPV35, HPV 39 and HPV45 were identified in 10/150 (6.7 %), 6/150 (4 %), 6/150 (4 %), 5/150 (3.3 %) and 10/150 (6.7 %), respectively. The frequency of these HPV subtypes among Yemeni women with cervical cancer was 24 %. Conclusion: HPV 31, HPV 33, HPV35, HPV 39 and HPV45 were prevalent among Yemeni women with cervical cancer.
Highlights
Cervical cancer is the third most common cancer in women Worldwide [1]
HPV45 were prevalent among Yemeni women with cervical cancer
Oncogenic human papillomavirus (HPV) is the most important risk factor associated with cervical cancer [2]
Summary
Oncogenic human papillomavirus (HPV) is the most important risk factor associated with cervical cancer [2]. HPV have been divided into high- and low-risk on the basis of their oncogenic potential. High risk HPV is considered to be the leading etiological cause for cervical cancer [3]. Cervical cancer is a very slow progressive disease which needs prolonged period to progress from normal to pre-cancer and to the potentially fatal invasive cancer. Identification of different HPV subtypes in unidentified communities provides sufficient information for screening and monitoring potential impact of a vaccination program. The aim of this study was to screen for the presence of HPVs subtypes 31,33,35,39 and 45 among Yemeni women with Cervical Cancer
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