Frequency of Helicobacter pylori in patients hemodialysis its correlation with demographic and biochemical factors; a single center study

Abstract

Introduction: Hemodialysis is one of the most common methods of treating chronic kidney disease (CKD). The start time of dialysis is determined depending on the clinical findings and subjective and objective parameters. However, factors such as patient perception and anxiety related to starting dialysis can modify these parameters. Patients on hemodialysis often have gastrointestinal complications; however, it is unclear whether Helicobacter pylori infection is more prevalent in these patients. Objectives: The aim of this study was to investigate the relative frequency of levels of H. pylori antibody in hemodialysis patients and its relationship with demographic and biochemical factors of hemodialysis patients in a hemodialysis center. Patients and Methods: The present study is a cross-sectional and the target population of patients is the hemodialysis center of Amin hospital in 2019. The sampling method was a non-probabilistic sampling. The sample size in the present study was 85 people. The collected information was entered into SPSS software version 22 and analyzed with appropriate statistical tests. The significance level in the present study was less than 0.05. Results: In total, 85 patients participated in the present study, of which 68% were men and the rest were women. The cut-off point and the positive and negative border of laboratory results for H. pylori were 18.8 U/mL. The mean level of H. pylori antibody was 87.353 ± 104.17 U/mL. In this study, significant relationship between the level of H. pylori antibody and Parathyroid hormone (PTH) was detected. PTH level was lower in patients with a positive result for H. pylori. No further relationship was detected between H. pylori infection and biochemical parameters and blood indices, as well as Kt/V and urea reduction rate (URR) was detected. Additionally, there was no significant difference in the mean level of H. pylori antibody between men and women. Accordingly, there was no significant correlation between H. pylori antibody level and age of patients, duration and number of dialysis sessions and body mass index. Conclusion: Based on the findings of the present study, mean level of PTH was significantly lower in patients with a positive result for H. pylori. No significant relationship was observed between H. pylori infection with other demographic and biochemical factors.