Frequency of Helicobacter Pylori in Patient with Stomach Cancer

Abstract

Background: Helicobacter pylori (H. pylori) infection is the important cause of chronic gastritis which results in atrophy and metaplasia of the underlying mucosa. Both these conditions are known to be associated with an increased risk of gastric carcinoma. The role of H. pylori infection in the pathogenesis of gastric cancer is an important but unresolved issue. Aim of the study: The aim of this study was to assess the frequency of H. pylori inpatient with stomach cancer. Methods: This was a cross-sectional study conducted in the Department of General Surgery in Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka from October 2019 to September 2020. The data regarding clinical and surgical profiles was recorded. Serum IgG, endoscopic biopsy, or campylobacter-like organism test (CLO) was performed for diagnosis of H. pylori. All the information is recorded in the data collection sheet. Data were processed and analyzed by SPSS and Microsoft excel. Results: The study demonstrates that a maximum number of patients (42.6%) were between 51-60-year age group; the mean age of the patient was 49.35±11.7 years. Out of 100 patients, 76.4% were male and 23.6% were female. The male and female ratio was 3.25:1. The differentiation and classification of gastric cancer were assessed according to Lauren's classification. Tumors of the intestinal type constituted 42(61.7%) of the tumors and diffuse was noted in 26(38.3%) of the tumors. The prevalence of H. pylori infection was 47(69.1%). The prevalence was significantly higher in intestinal than in diffuse-type carcinoma. The difference was statistically significant (P<0.05). Conclusion: The present study concluded that the prevalence of H. pylori infection is 69.1% in patients with carcinoma stomach. Prevalence of intestinal-type carcinoma stomach is more than diffuse type. There was an important difference in H. pylori prevalence between the intestinal and diffuse types of gastric cancer. Control of H. pylori .............