Frequency of FLT3/ITD Mutation in Patients with Acute Myeloid Leukaemia presenting at Combined Military Hospital, Rawalpindi

Abstract

Objective: To assess the frequency of FLT3/ITD mutation in patients of Acute myeloid leukaemia presenting at Combined Military Hospital, Rawalpindi Pakistan. Study Design: Cross-sectional study. Place and Duration of Study: Oncology Department, Combined Military Hospital, Rawalpindi Pakistan, from Jan to Jun 2020. Methodology: A sample of 46 patients with acute myeloid leukaemia was included using a non-probability, consecutive sampling technique. Genetic testing was done on all blood samples to identify FLT3-ITD mutation. Results: Out of 46, 10(21.7%) were females and 36(78.3%) were males. The FLT3/ITD mutation frequency in our study sample was 10(21.7%), with all in de-novo AML patients and none in secondary AML. White cell count (55x109), bone marrow blasts (85%) and peripheral smear blasts (75%) were high in the FLT3-ITD mutated group in comparison to the non-mutated group. Conclusion: Timely detection of FLT3/ITD mutation and an amplification of induction therapy would benefit this group of patients.