Abstract
This article presents the results of studies obtained by observing patients with non-alcoholic fatty liver disease (NAFLD) on the background of chronic obstructive pulmonary disease (COPD). As a result of the analysis it was found that the frequency of exacerbations of COPD with hospitalization in overweight patients in the presence of NAFLD leads to increased imbalance of adipose tissue hormones in the form of decreased adiponectin and increased leptin, and correlates with impaired lipid metabolism and severe grade of hepatic steatosis. In patients with frequent exacerbations, there is a significant positive correlation between leptin levels and TNF-a factor, which may be associated with an increase in overall inflammation. The revealed imbalance of adiponectin and leptin content in patients with COPD with overweight is a factor in the progression of NAFLD.
Highlights
According to GOLD, patients with chronic obstructive pulmonary disease (COPD) often have a common metabolic syndrome
As a result of the analysis, it was found that all patients with nonalcoholic fatty liver disease (NAFLD) and NAFLD + COPD had significantly reduced levels of adiponectin and elevated levels of leptin
The most pronounced changes were registered in patients with NAFLD, who last year had more than 2 exacerbations of COPD with hospitalization and belonged to GOLD II
Summary
According to GOLD, patients with chronic obstructive pulmonary disease (COPD) often have a common metabolic syndrome. It is 23%53% and depends on the stage and degree of inflammation. COPD and nonalcoholic fatty liver disease (NAFLD) have common pathophysiological mechanisms, such as decreased physical activity, oxidative stress, low-intensity inflammation, and metabolic syndrome. The severity of COPD is recognized as an independent risk factor for NAFLD [4]. Insufficient determination of the factors of unity of pathogenetic mechanisms of NAFLD progression on the background of COPD and the lack of uniform recommendations for the treatment of patients with comorbid pathology has led to the relevance of our studies
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