Abstract
he frequency of EGFR mutations is ethnicity-dependent, with a higher proportion in Asian population than in whites. The prevalence of these mutations among Arab patients is unknown. The objective of this study was to report the frequency and spectrum of EGFR mutations in our population with lung adenocarcinoma, and the effect of this mutation on treatment outcome. Tumor specimens from 81 patients histological diagnosed as NSCLC adenocarcinoma were reviewed by our local pathologist and then sent to Lab 21 London, UK. Samples were tested for 28 mutations in EGFR gene. Positive patients received TKI and negative patients received chemotherapy. Data were collected and retrospectively analyzed to determine frequency and spectrum of EGFR positivity. Patients were followed for time to progression (TTP) and overall survival (OS). Overall frequency of EGFR mutation was 37%; Del 19 (46.6%), L858R (40%), D719x and insertion 20 (6.7%) for each. Females and nonsmokers exhibited a statistically significant higher EGFR positivity (P = 0.003, 0.059) respectively. Overall response rate (ORR) was 76.6% and 43% in EGFR positive and negative cases respectively (P = 0.002). There was a statistically significant difference in TTP and OS between EGFR positive and negative patients (P = 0.035 and 0.039 respectively). Arab patients exhibit an EGFR mutation pattern that is closer to Asian population. EGFR gene mutation subtypes are the same as that reported worldwide. A statistically significant TTP and OS benefit was noticed in EGFR positive patients compared to EGFR negative cases.
Highlights
Worldwide, approximately 1.5 million new cases of lung cancer are diagnosed each year
Between June 2010 and February 2013, 81 patients received at Kuwait Cancer Control Center (KCCC) Outpatient Clinic were diagnosed with NSCLC
Core tissue biopsies from those patients were reviewed by local pathologists, and samples were sent to Lab 21 London, UK to be tested for EGFR mutation using
Summary
Approximately 1.5 million new cases of lung cancer are diagnosed each year. According to Kuwait Cancer Registry 2010, the incidence of lung cancer is 12.9 cases/100,000 persons every year; about half of the patients are adenocarcinoma [1]. Platinum-based chemotherapy is considered standard of care worldwide for patients with advanced NSCLC. Patients who are never smokers, females, adenocarcinomas, and Asians have a relatively high incidence of somatic mutations in the region of the EGFR gene that encodes the tyrosine kinase domain [3]. Mutations in the EGFR tyrosine kinase are observed in approximately 15% of NSCLC adenocarcinoma in the United States and occur more frequently in nonsmokers. In Asian populations, the incidence of EGFR mutations is substantially higher, reaching up to 62% [4]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
