Frequency of CYP1A1*2A polymorphisms and deletion of the GSMT1 gene in a Peruvian mestizo population

Abstract

The polymorphic variants ofCYP1A1and the deletion ofGSTM1are present in the Peruvian mestizo population. Wild type and mutated genotypes (WT/*2A and *2A/ *2A) were identified, whose allele frequencies are 0.31 (T allele) and 0.69 (C allele), respectively; 53% with wild typeGSTM1(+) and 47% with nullGSTM1. The frequency in Iquiteño emigrants was 0.72CYP1A1*2Aand 25%GSTM1(-); from Lima 0.67CYP1A1*2Aand 33% ofGSTM1(-). The Hardy-Weinberg equilibrium test for the studied population showed that both frequencies are out of balance, p > .05.The presence of the risk allele of theCYP1A1*2Apolymorphism and the deletion in theGSTM1gene are high, which could be indicative of a phase I and II metabolic imbalance in this group of Peruvian populations, with potential risks of activating agents procarcinogens thus affecting the incidence of tumor pathologies with an environmental component.