Abstract
Background and objectiveCeliac disease is an autoimmune multisystem disorder that is triggered by dietary gluten sensitivity in genetically susceptible individuals. It presents with extraintestinal cutaneous manifestations including dermatitis herpetiformis (DH), atopic dermatitis, psoriasis, urticaria, and alopecia areata. Due to the insufficient availability of data, this study aimed to estimate the frequency of cutaneous manifestation in a Pakistani population with celiac disease.MethodsThis cross-sectional study was conducted from January 2020 to July 2021, and 300 patients with a confirmed diagnosis of celiac disease were enrolled in the study from the internal medicine department of a tertiary care hospital in Pakistan. Celiac disease was confirmed by the presence of immunoglobulin A (IgA) endomysial antibody and IgA tissue transglutaminase antibody. The presence of cutaneous manifestations was assessed with the assistance of a qualified dermatologist and noted in a self-structured questionnaire.ResultsOverall, the most common cutaneous manifestation was DH (16.0%), whereas the second most common cutaneous manifestation was psoriasis (13.8%). DH was most commonly found among males (18.9%), while psoriasis was more common among females (14.12%).ConclusionAmong the various cutaneous presentations in patients with celiac disease, the most common dermatological manifestation was DH. Therefore, patients with cutaneous manifestations should undergo screening for celiac disease.
Highlights
Celiac disease is an autoimmune disorder, and it is triggered by dietary gluten sensitivity among genetically susceptible individuals [1]
Celiac disease was confirmed by the presence of immunoglobulin A (IgA) endomysial antibody and IgA tissue transglutaminase antibody
dermatitis herpetiformis (DH) was most commonly found among males (18.9%), while psoriasis was more common among females (14.12%)
Summary
Celiac disease is an autoimmune disorder, and it is triggered by dietary gluten sensitivity among genetically susceptible individuals [1]. The classic presentation consists of gastrointestinal symptoms; failure to thrive, diarrhea, bloating, and abdominal pain. Such classic symptoms are more likely to be seen in patients aged
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