Frequency Distribution of Prostatic Lesions in Males at Gadarif Advanced Medical Diagnostic Centre, Gadarif State Eastern Sudan

Abstract

The prostate gland is a male reproductive organ, mostly affected by diseases. Prostate cancer is the most diagnosed cancer among men and causes mortality and morbidity in elderly males. The present study was carried out to determine the pattern of prostatic lesions in male patients at Gadarif Advanced Medical Diagnostic Centre, Gadarif State, Eastern Sudan from October 2017 to September 2019. For this retrospective descriptive investigation, the analysis of histopathological records of 167 cases of prostate lesions showed the mean age of 71±9.6 years; most of the patients being in the age group 61-70 years represented 67(40.1%) cases. The most common patterns of the prostatic lesions were benign prostatic hyperplasia accounted for 124 (74%) cases, 85(68.5 %) of them having chronic prostatitis on top of the benign prostatic hyperplasia, the second pattern was adenocarcinoma which accounted for 42 cases. 32(19.2) malignant cases showed PSA levels >24 ng/ml, which revealed strong correlation between the increase in PSA levels and malignant lesions (p= 0.000). The most frequent Gleason scores were 7 and 9 and Gleason’s grade 3 was the most common histologic grade found in 16 (41%) cases. The present study revealed that benign prostatic hyperplasia was the most common lesion followed by adenocarcinoma and increased in elderly males. A strong correlation between increasing PSA levels and adenocarcinoma was established. Keywords: Prostatic gland, histopathology, benign prostatic hyperplasia, adenocarcinoma, PSA