Abstract
Cervical cancer is the most important female gynecological cancer, the second leading cause of cancer mortality in women worldwide and the second most common cancer in Thai women. The major cause of cervical cancer is persistent infection of human papillomavirus (HPV), leading to abnormal epithelial lesions, with progression to precancerous and invasive cancer. This study was conducted to investigate the frequency and type distribution of HPV in Thai women who had abnormal cytology. HPV detection from FFPE confirmed abnormal of high grade cervical intraepithelial lesions were for SPF-10-Innogenic Line Probe Assay. HPV-positivity was detected in 320/355 cases (90.14%) and HPV-negativity in 35/355 (9.86%). HPV-positive was found 147/320 cases (41.4%) of single infection, whereas 173/320 cases (48.7%) showed the multiple HPV infection. The most common seven types were HPV-16, -52, -18, -11, -51, -31 and -33, in that order. HPV 16 and 18, the important oncogenic HPV type, were observed in 64.8% of HSIL cases. Interestingly, a high proportion of multiple infections was found in this study and more than ten types could be detected in one case. Therefore, HPV infection screening program in women is essential, particularly in Thailand. Effective primary and secondary prevention campaigns that reinforce HPV screening for HPV detection and typing may be decrease the incidence and mortality of cervical cancer in the future and may lead to significantly improve the quality of life in Thai women.
Highlights
Cervical cancer is the most common cause of cancer death in Thai woman
Human papillomavirus (HPV) detection from Formalinfixed Paraffin Embedded Tissue (FFPE) confirmed abnormal of high grade cervical intraepithelial lesions were for SPF-10-Innogenic Line Probe Assay
15 HPV type associate with high grade epithelial cervical neoplasia, invasive cervical and other anogenital cancer have been categorized as high-risk types such as HPV 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, 73 and 82, whereas the HPV types which found primarily in genital wart or non-malignant lesion were designed as low-risk types such as HPV 6, 11, 40, 42, 43, 44, 54, 61, 72, 81, 83, 84; (IARC, 1995; Zur, 2002; Bharti et al, 2010)
Summary
The incidence of new cases per years is 9999 and mortality is about 50% (Munoz, 2000). The etiology of this cancer is Human papillomavirus (HPV). 15 HPV type associate with high grade epithelial cervical neoplasia, invasive cervical and other anogenital cancer have been categorized as high-risk types such as HPV 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, 73 and 82, whereas the HPV types which found primarily in genital wart or non-malignant lesion were designed as low-risk types such as HPV 6, 11, 40, 42, 43, 44, 54, 61, 72, 81, 83, 84; (IARC, 1995; Zur, 2002; Bharti et al, 2010). There are some HPV types that can not be exactly classified into high-risk type such as HPV 26, 53 and 66, categorized as probable high-risk type (Bharti et al, 2010)
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