Frequency and timing of thoracic tumor spread in 198 consecutive patients with advanced-stage high-grade serous ovarian cancer (HGSC).

Abstract

5575 Background: HGSC is the most common type of ovarian cancer. While routinely used, the necessity of chest CT in these patients is unknown. We hypothesize that thoracic metastases in HGSC occur late, after development of abdominal disease. We aimed to describe the frequency and timing of occurrence of thoracic disease in advanced (stage III and IV) HGSC in relation to the abdominal disease. Methods: In this IRB-approved, HIPAA-compliant retrospective study, we included 198 consecutive patients with pathologically proven advanced HGSC seen from January 2012 through December 2012 (mean age 60 years, SD±9.5 years; median follow-up 40 months, IQR 25-63). Time to development of abdominal and thoracic disease and survival thereafter was recorded by review of thoracic and abdominal imaging and electronic medical records, and compared using Mann-Whitney test. Predictors of occurrence and time to development of thoracic disease were identified using multivariate analysis. Results: Abdominal disease developed in...