Frequency and safety of intracoronary acetylcholine provocation testing compared to coronary interventions: Analysis of a contemporary Japanese multicenter PCI registry

Abstract

Vasospastic angina (VSA) is recognized as an important cardiovascular disorder characterized by transient myocardial ischemia due to epicardial coronary artery spasm, particularly in East Asians [1,2]. The Japanese Circulation Society guideline suggests that the findings from intracoronary acetylcholine (ACh) injection are crucial for the diagnosis of VSA. However, its real-world execution rate, diagnostic results, and safety remain largely unclear. Furthermore, VSA is becoming increasingly recognized in Western countries [3], and this information remains to be explored under universal definition.