Abstract
Background:Infertility is defined as inability of couple to conceive after one year of unprotected intercourse. The prevalence of infertility in Pakistan is 21.9%. The most common cause of medically treatable infertility is polycystic ovarian syndrome (PCO). This study was conducted to see the frequency and outcome of treatment in PCOs related infertility in infertile couples coming to Mohammad Medical College Hospital, Mirpurkhas, Sindh.Methods:This prospective observational study was conducted at Muhammad Medical College for three years from 2005 to 2008. Total 1289 infertile couples were included in this study.Result:The frequency of PCOs in female related infertility was 38.5%. Other causes of female infertility were in the frequency of 44% pelvic inflammatory disease, 12.3% endometriosis, 2.9% hyperprolactenemia, and 1.35% hypothyroidism. Patients with PCOS were given different treatment modalities. One hundred fifty patients with PCO were given ovulation induction with clomephene citrate and out of them 109 (72%) conceived. Sixty three women were given combination of clomephene citrate and Metformin. Out of them 50 (79%) conceived. Five patients were given gonadotrophins, Out of them 2 (40%) patients conceived. Five patients had laparoscopic drilling out of them 3 (60%) conceived.Conclusion:In contrast to the literature review Polycystic Ovarian Syndrome turned out to be the second most common cause of female related infertility. But as the international literature shows it had very good out come after medical and /or surgical treatment.
Highlights
Infertility is a worldwide problem which has profound social and emotional implications for the individual concerned
In Poly cystic ovarian syndrome (PCOS) Increased ovarian androgen production leads to premature adrenarche, menstrual irregularity, acne, hirsutism, and infertility by means of elevated luteinizing hormone to follicle stimulating hormone production and hyperinsulinemia. 6
In this study polycystic ovarian syndrome (PCO) related infertility turned out to be the second most common cause of female factor related infertility that is 38.5%.A study was done to see the prevalence of PCOS in Pakistan it turned out to be 20.7%.This retrospective study was carried out at Women Clinic and fertility advisory center, Islamabad from Jan. 1997 to May 1999 on 52 women having polycystic ovary syndrome with fertility deprivation
Summary
Infertility is a worldwide problem which has profound social and emotional implications for the individual concerned. The most common cause of treatable infertility is polycystic ovarian syndrome, common in young women and cause of an ovulatory infertility in 70% cases.[3] The World Health Organization classification offers a useful frame for diagnosis and treatment. The most common cause of medically treatable infertility is polycystic ovarian syndrome (PCO). This study was conducted to see the frequency and outcome of treatment in PCOs related infertility in infertile couples coming to Mohammad Medical College Hospital, Mirpurkhas, Sindh. Result: The frequency of PCOs in female related infertility was 38.5%. One hundred fifty patients with PCO were given ovulation induction with clomephene citrate and out of them 109 (72%) conceived. Conclusion: In contrast to the literature review Polycystic Ovarian Syndrome turned out to be the second most common cause of female related infertility. As the international literature shows it had very good out come after medical and /or surgical treatment
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