Abstract

Backgroundhemorrhagic transformation is a threatening ischemic stroke complication. Frequency of hemorrhagic transformation differs greatly among studies, and its risk factors have been usually studied in patients with anterior ischemic stroke who received thrombolytic therapy. We evaluated, in a hospital-based series of patients with posterior ischemic stroke not treated with thrombolysis, frequency and risk factors of hemorrhagic transformation. Patients with posterior circulation stroke were seen in our Department during the period January 2004 to December 2009. Demographic and clinical information were collected. We estimated risk for spontaneous hemorrhagic transformation by means of uni- and multivariate logistic regression analyses.Results119 consecutive patients were included (73 males, 61.3%). Hemorrhagic transformation was observed in 7 patients (5.9%). Only clinical worsening was significantly associated with hemorrhagic transformation (OR 6.8, 95% CI 1.3–34.5).ConclusionsOur findings indicate that patients with posterior have a low risk of spontaneous hemorrhagic transformation, suggesting that these patients might have greater advantage from intravenous thrombolysis.

Highlights

  • Neurological and medical complications of ischemic stroke (IS) are responsible for higher morbidity and mortality

  • Thrombolytic therapy significantly reduces the proportion of patients dead or dependent in activities of daily living, it significantly increases the risk of hemorrhagic transformation (HT) of the ischemic lesion, complication that

  • One-hundred fifty-six patients were admitted to our Department during the study period for symptoms attributable to posterior circulation

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Summary

Introduction

Neurological and medical complications of ischemic stroke (IS) are responsible for higher morbidity and mortality. The former occur earlier than medical complication, and they affect outcomes with potential serious short- and long-term consequences [1]. Thrombolytic therapy significantly reduces the proportion of patients dead or dependent in activities of daily living, it significantly increases the risk of hemorrhagic transformation (HT) of the ischemic lesion, complication that. We have previously investigated frequency and risk factors for HT of the anterior ischemic stroke [3, 4]. We have investigated frequency and risk factors for spontaneous HT in a sample of patients with posterior IS, treated only with conventional therapy, not undergoing thrombolysis. To individuate patients with posterior ischemic stroke suitable for thrombolytic therapy, it is Valentino et al BMC Res Notes (2017) 10:592 critical to estimate frequency of spontaneous HT among ischemic stroke patients, and determine its risk factors

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